Pneumolysin Potentiates Production of Prostaglandin E 2 and Leukotriene B 4 by Human Neutrophils
- 1 May 2001
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 69 (5) , 3494-3496
- https://doi.org/10.1128/iai.69.5.3494-3496.2001
Abstract
Exposure to pneumolysin (8.37 and 41.75 ng/ml) caused a calcium-dependent increase in the generation of prostaglandin E 2 and leukotriene B 4 by both resting and chemoattractant-activated human neutrophils in vitro. These interactions of pneumolysin with neutrophils may result in dysregulation of inflammatory responses during pneumococcal infection.Keywords
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