Quinidine-Induced Neutropenia: Report of a Case with Drug-Dependent Inhibition of Granulocyte Colony Generation

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Abstract
We describe a case of quinidine-induced agranulocytosis in which in vitro marrow culture studies suggested immune inhibition of committed human granulocytemacrophage progenitors (CFU-GM). Autologous, but not allogeneic, inhibition of CFU-GM was seen with ‘acute’ serum from the patient in the presence of quinidine but not other drugs. Cytotoxic antibodies to mature granulocytes were not found. These studies provide a novel mechanism for drug-induced neutropenia and suggest that a battery of in vitro assays of progenitor and of mature granulocyte cytotoxicity might identify offending agents in suspected drug-induced neutropenias.

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