A novel recombinant HLA-B*39 allele (B*3910) in a South African Zulu
- 1 November 1996
- journal article
- Published by Wiley in Tissue Antigens
- Vol. 48 (5) , 595-597
- https://doi.org/10.1111/j.1399-0039.1996.tb02676.x
Abstract
The sequence of a new B*39 allele has been identified in a South African Zulu individual. This allele designated B*3910, differs at two nucleotide positions (246 and 272) from B*39011. The difference at position 246 is silent, while that at position 272 results in an amino acid change from cysteine (B*39011) to tyrosine (B*3910). As these same differences are found in other HLA-B alleles, they were probably introduced into the B*3910 sequence by a short gene conversion event with another allele. This finding provides further evidence for the diversification of HLA-B allelic sequences via recombination.Keywords
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