Actions of prostaglandin F2α on the splenic vascular and capsular smooth muscle in the dog

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Abstract
1 The actions of prostaglandin F2α, which is known to be released by the spleen on sympathetic nerve stimulation, have been investigated in the isolated blood perfused spleen of the dog. 2 Low arterial concentrations of F2α (less than 10 μg/100 ml) caused marked reductions in splenic vascular resistance. 3 High arterial concentrations of F2α (above 10 μg/100 ml) caused increases in splenic vascular resistance. 4 Little action on splenic volume was observed by any arterial concentration of F2α. 5 The reductions in splenic vascular resistance caused by low arterial concentrations of F2α were reversed by blocking doses of phenoxybenzamine. 6 No appreciable interaction between F2α and the splenic responses to sympathetic nerve stimulation, adrenaline and noradrenaline was observed. 7 The role of the prostaglandins released by the spleen is discussed.