Two Genes Link Two Distinct Psychoses
- 18 November 2005
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 310 (5751) , 1128-1129
- https://doi.org/10.1126/science.1121114
Abstract
Disrupted in schizophrenia 1 (DISC1), the first gene directly linked to schizophrenia, appears to regulate neuronal growth and migration. In their Perspective, Sawa and Snyder discuss the study by Millar et al. that reports the interaction of DISC1 with the enzyme phosphodiesterase 4B (PDE4B). PDE4B is now reported as aberrant in a schizophrenic family. The interaction of the two proteins controls PDE4B activity and may modulate mood and mentation both physiologically and pathophysiologically.Keywords
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