Cis(Z)-clopenthixol and clopenthixol (Sordinol®) in chronic psychotic patients: A DOUBLE-BLIND CLINICAL INVESTIGATION

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Abstract
The clinical effect of the neuroleptic cis(Z)-clopenthixol was compared with that of clopenthixol, which is a mixture of the pharmacologically active cis(Z)-isomer and the inactive trans(E)-isomer. In the 2-mo. double-blind trial were included 57 psychotic patients, mainly schizophrenics. Ratings evaluating severity of illness, therapeutic effect, possible interference of side-effects with the patients functioning and any individual side-effects were done at months 0, 1 and 2. The antipsychotic effect of cis(Z)-clopenthixol was equal to that of clopenthixol whereas the cis(Z)-isomer on a mg/mg basis was twice as active as clopenthixol. Apart from the finding that the unspecific sedative effect appeared to be less marked with cis(Z)-clopenthixol, the type, degree and frequency of side-effects were the same in the 2 groups of patients. More than half of the patients experienced no side-effects.

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