Tolbutamide treatment of pregnant mice: Repeated administration reduces fetal lethality
- 1 February 1976
- journal article
- research article
- Published by Wiley in Teratology
- Vol. 13 (1) , 65-70
- https://doi.org/10.1002/tera.1420130111
Abstract
Pretreatment of pregnant BALB/c mice with several low doses of tolbutamidc protected against the fetolethal effects of a high dose. Pregnant mice were given single ip injections of 400 mg/kg in saline on day 13; 100 mg/kg/day on clays 10, 11, 12, and 13; or 100 mg/kg/day on days 10, 11, and 12 and 400 mg/kg on day 13. On day 16 the single‐treatment group had a significantly higher resorption rate than any other group. Fetolethality was not related to hypoglycemia. The protective effect of pretreatment may have been due to induction of maternal microsomal enzymes.Keywords
This publication has 10 references indexed in Scilit:
- Experimental modification of patterns of cell death and chondrogenesis in insulin-induced micromelia of the developing chick limb: An autoradiographic analysis of35SO4 uptake into chondroitin sulfateTeratology, 1974
- Metabolic Interactions Among Environmental Chemicals and DrugsScience, 1972
- Inhibition by ethylmorphine and pentobarbitone in vitro of the metabolism of [ureyl-14C]tolbutamide by hepatic microsomal preparations from male and female rats treated with phenobarbitoneBiochemical Pharmacology, 1972
- Is insulin a teratogen?Teratology, 1972
- Factors Altering the Responsiveness of Mice to HexobarbitalPharmacology, 1968
- Metabolic studies of tolbutamide in the ratBiochemical Pharmacology, 1967
- Effect of Red Cedar Chip Bedding on Hexobarbital and Pentobarbital Sleep TimeJournal of Pharmaceutical Sciences, 1966
- Toluidine Blue-Alizarin Red S Staining of Cartilage and Bone in Whole-Mount Skeletons in VitroStain Technology, 1965
- Teratogenic effects of hypoglycemic treatments in inbred strains of miceJournal of Anatomy, 1963
- An o-Toluidine Method for Body-Fluid Glucose DeterminationClinical Chemistry, 1962