H–2-linked genes control immune response to V-domains of myeloma protein 315

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Abstract
Immunoglobulins function as antigen receptors of B lymhocytes and as effector molecules for elimination of foreign antigens. Idiotypes (antigenic sites of variable (V) domains) bound on the surface of plasmacytomas can act as tumor-specific transplantation antigens. Optimal maturation of B lymphocytes of a given idiotype into antibody-secreting cells seems to require assistance from 2 kinds of helper T cells (Th), 1 bearing receptors complementary or similar to that idiotype, and another that recognizes the antigen. To learn more about recognition of V regions by Th, V-domains of IgA (.lambda.2) myeloma protein M315 produced by the BALB/c plasmacytoma MOPC 315 were used as carriers for anti-hapten responses. The Th response to the V-domain of the H-chain (VH) and the L-chain (VL) of M315 seems to be under H-2-linked immune response (IR) gene control.

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