Purine Functionalized Congeners as Molecular Probes for Adenosine Receptors
- 1 July 1991
- journal article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 10 (5) , 1029-1038
- https://doi.org/10.1080/07328319108047240
Abstract
The effects of distal structural changes on biological activity may be studied, using a “functionalized congener” strategy, in which suitably placed chemically reactive chains lead to biologically active conjugates. Probes for photoaffinity labeling, chemical affinity labeling, spectroscopic characterization and affinity chromatography of adenosine receptors have been derived from purine amine congeners (XAC, ADAC for A1-receptors and APEC for A2-receptors). Also, drug conjugates, including prodrugs and lipids, have been designed as potential pharmacological agents.This publication has 18 references indexed in Scilit:
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