Leukocytic Response to Inhaled Bacteria1–3
- 1 October 1977
- journal article
- research article
- Published by American Thoracic Society in American Review of Respiratory Disease
- Vol. 116 (4) , 679-684
- https://doi.org/10.1164/arrd.1977.116.4.679
Abstract
Using histologic techniques, we have quantified the amount of infiltration of bronchi and alveoli by polymorphonuclear leukocytes during the 4 hours after an aerosol inoculation of mice with bacteria. Although the lungs of animals challenged with Staphylococcus aureus differed little from those of animals exposed only to a water aerosol, the lungs of animals exposed to Klebsiella pneumoniae or to Escherichia coli demonstrated significantly greater polymorphonuclear leukocyte infiltrations in bronchi and alveoli 2 and 4 hours after exposure. These results suggest that the polymorphonuclear leukocyte may contribute to the early defense of the lung against some bacteria.This publication has 2 references indexed in Scilit:
- Enhancement of bactericidal capacity of alveolar macrophages by human alveolar lining material.Journal of Clinical Investigation, 1976
- Murine Pulmonary Alveolar Macrophages: Rates of Bacterial Ingestion, Inactivation, and DestructionThe Journal of Infectious Diseases, 1976