Effects of prostaglandins on ovarian blood flow in the bitch

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Abstract
Estrous and anestrous mongrel dogs were anesthetized with chloralose-urethane. In 1 group, the ovaries were isolated in situ and the effects of a 15 min infusion of Pg[prostaglandin]F-2.alpha. or PGE-2 on perfusion pressure were measured. In the other group, heated thermocouples were introduced into the stroma of each ovary to measure the changes of local blood flow in response to PGF-2.alpha. and PGE-2 infused into the ovarian bursa for 15 min. Intra-arterial infusion of 25, 50, 100 or 200 ng PGF-2.alpha./kg per min did not affect perfusion pressure; PGE-2 doses of 3.1, 6.2, 12.5 or 25 ng/kg per min caused reductions in proportion to the dose. All doses of PGF-2.alpha. (50.0, 100 or 200 ng/kg per min) or PGE-2 (25, 50 or 100 ng/kg per min) increased blood flow in the ovarian stroma in porportion to the dose when administered by infusion into the ovarian bursa. There were no differences in the results from estrous and anestrous dogs. PGF-2.alpha. changes intraovarian blood distribution without interfering with the total blood flow while PGE-2 increases the total and local ovarian blood flow.

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