Serum Bactericidal Activity of Moxalactam and Cefotaxime With and Without Tobramycin Against Pseudomonas aeruginosa and Staphylococcus aureus
Open Access
- 1 October 1981
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 20 (4) , 539-541
- https://doi.org/10.1128/aac.20.4.539
Abstract
Serum bactericidal activity was determined against 10 strains each of Pseudomonas aeruginosa and Staphylococcus aureus in serum from volunteers 1 and 6 h after intravenous infusion of cefotaxime, tobramycin, and the combination; or of moxalactam, tobramycin, and the combination. High serum bactericidal activity against P. aeruginosa was found significantly more frequently with moxalactam plus tobramycin than with cefotaxime, moxalactam, and tobramycin alone or with cefotaxime plus tobramycin.This publication has 13 references indexed in Scilit:
- Activity of cefotaxime-aminoglycoside combinations against aminoglycoside-resistant PseudomonasAntimicrobial Agents and Chemotherapy, 1980
- Comparison of in vitro activity of moxalactam (LY127935) with cefazolin, amikacin, tobramycin, carbenicillin, piperacillin, and ticarcillin against 420 blood culture isolatesAntimicrobial Agents and Chemotherapy, 1980
- LY127935, a novel oxa-beta-lactam: an in vitro comparison with other beta-lactam antibioticsAntimicrobial Agents and Chemotherapy, 1979
- Antibacterial Activity of a New 1-Oxa Cephalosporin Compared with That of Other β-Lactam CompoundsAntimicrobial Agents and Chemotherapy, 1979
- Antibacterial Activity of a New Parenteral Cephalosporin—HR 756: Comparison with Cefamandole and CeforanideAntimicrobial Agents and Chemotherapy, 1979
- In Vitro Activity of Cefotaxime Against Cephalothin-Resistant Clinical IsolatesAntimicrobial Agents and Chemotherapy, 1979
- Serum Dilution Test for Bactericidal Activity. II. Standardization and Correlation with Antimicrobial Assays and Susceptibility TestsThe Journal of Infectious Diseases, 1977
- Significance of antimicrobial synergism for the outcome of gram negative sepsisThe Lancet Healthy Longevity, 1977
- Use of Sodium Polyanethol Sulfonate to Selectively Inhibit Aminoglycoside and Polymyxin Antibiotics in a Rapid Blood Level Antibiotic AssayAntimicrobial Agents and Chemotherapy, 1976
- Antibacterial Activity in Serum and Urine as a Therapeutic Guide in Bacterial InfectionsThe Journal of Infectious Diseases, 1974