Passive transfer studies in demyelinating neuropathy with IgM monoclonal antibodies to myelin-associated glycoprotein.
Open Access
- 1 September 1985
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 48 (9) , 927-929
- https://doi.org/10.1136/jnnp.48.9.927
Abstract
Serum or IgM fraction from two patients with a demyelinating neuropathy and IgM monoclonal antibodies to myelin-associated glycoprotein were injected in three different animal species. There were no clinical, electrophysiological or morphological signs of demyelination in either chronic or acute passive transfer experiments. These results suggest that the pathogenesis of this human demyelinating neuropathy may be more complex than has been assumed.Keywords
This publication has 13 references indexed in Scilit:
- Chronic inflammatory polyneuropathyJournal of the Neurological Sciences, 1984
- Microangiopathy of vasa nervorum in dysglobulinemic neuropathyAnnals of Neurology, 1984
- Polyneuropathy in Waldenström's macroglobulinaemia: Reduction of endoneurial IgM-deposits after treatment with chlorambucil and plasmapheresisActa Neuropathologica, 1984
- Peripheral neuropathy with IgM kappa monoclonal immunoglobulin directed against myelin‐associated glycoproteinNeurology, 1983
- Human monoclonal antibodies to myelin-associated glycoproteinJournal of Neuroimmunology, 1983
- Neuropathy accompanying IgM? monoclonal gammopathyActa Neuropathologica, 1983
- Demyeliating neuropathy and monoclonal IgM antibody to myelin‐associated glycoproteinNeurology, 1983
- Myelin‐Associated Glycoprotein Is the Antigen for a Monoclonal IgM in PolyneuropathyJournal of Neurochemistry, 1982
- Myeloma Neuropathy: Passive Transfer from Man to MouseScience, 1981
- AUTOIMMUNE AETIOLOGY FOR MYASTHENIC (EATON-LAMBERT) SYNDROMEThe Lancet, 1981