Variability in the Measure of Total Ascorbic Acid Utilization by the Human

Abstract
The two factors of variability studied have been an outgrowth of an investigation of total ascorbic acid utilization by the human. The factors are the carry-over effect of previous intake of total ascorbic acid on subsequent data and the effect of the same amount of a test dose of ascorbic acid given either at a single time or divided by an interval of time. In addition, the sensitivity of blood plasma and urine measurements as a means to differentiate changes in ascorbic acid intake has been studied. Total ascorbic acid measurements of the blood plasma and of 24-hour urine returns were the measures. From the data obtained under the conditions of these experiments it is concluded that: