Biosynthese de la carcinine (β-alanyl-histamine)in vivo

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Abstract
Carcinine was biosynthesized by Carcinus maenas from [14C]β-alanine, [14C] histidine and [14C] histamine. Since carnosine ((β-alanyl-histidine) could not be detected in crab tissues, biosynthesis of carcinine could only be effected by direct coupling of β-alanine and histamine resulting from histidine decarboxylation. Biosynthesis of carcinine was weak when [14C] β-alanine and [14C] histidine were used as precursors. On the contrary when [14C] histamine was used, synthesis was important. Thus carcinine appears to be a product of histamine catabolism. After injecting [14C] histamine, radioactive carcinine was concentrated mainly in the heart and nervous system; non-metabolized [14C] histamine was recovered mainly in the latter. The nervous system might therefore be the seat of carcinine biosynthesis and thus the site of action of histamine. Résumé

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