TGTG, G clustering and Other Signals Near Non-Mammalian Vertebrate mRNA 3′ Termini: Some Implications
- 1 June 1986
- journal article
- research article
- Published by Taylor & Francis in Journal of Biomolecular Structure and Dynamics
- Vol. 3 (6) , 1145-1153
- https://doi.org/10.1080/07391102.1986.10508491
Abstract
Analysis of non-mammalian vertebrate DNA sequences in the 500 nucleotides preceding and 200 nucleotides following mRNA 3′ termini yields some distinct signals. In addition to the well known AATAAA sequence, TGTG recurs very frequently further downstream. GGGG, TGGG, GGAG and GAGG are frequent in this region too. It is suggested that unlike the AATAAA mRNA cleavage/processing signal, the other signals noted above are signals on the DNA, i.e. they are signals for mRNA termination. An asymmetric distribution of some complementary sequences, e.g. TGTG vs. CACA, GGGG vs. CCCC, on the same DNA strand is noted as well. A few other signals are also observed.This publication has 16 references indexed in Scilit:
- Some guidelines for identification of recognition sequences: Regulatory sequences frequently contain (T)GTG/CAC(A), TGA/TCA and (T)CTC/GAG(A)Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1986
- Transcription termination and 3′ processing: the end is in site!Cell, 1985
- The crystal structure of d(G-G-G-G-C-C-C-C) a model for poly(dG) · poly(dC)Journal of Molecular Biology, 1985
- The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3′ terminiNucleic Acids Research, 1985
- Requirement of a downstream sequence for generation of a poly(A) addition siteCell, 1984
- Correlation of lac operator DNA imino proton exchange kinetics with its function.Proceedings of the National Academy of Sciences, 1984
- DNA structural variations in the E. coli tyrT promoterCell, 1984
- Possible Molecular Detent in the DNA Structure at Regulatory SequencesJournal of Biomolecular Structure and Dynamics, 1983
- Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3′ consensus sequence AAUAAANature, 1983
- 3′ Non-coding region sequences in eukaryotic messenger RNANature, 1976