Effect of sex hormones on lipid peroxidation in rat liver

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Abstract
The role of sex hormones in hepatic lipid peroxidation, and in hepatic aldehyde oxidase and xanthine oxidase activities were investigated using rat liver homogenates. It was observed that male rat had a significantly greater content of malondialdehyde in liver than female. Among the sex hormones tested, estradiol, one of female hormones, markeldy inhibited the formation of lipid peroxides in liver tissuesin vitro. Especially, the inhibitory effect of estradiol appeared more remarkably in Fe2-induced lipid peroxidation. The hepatic xanthine oxidase activity was decreased about 15% by 106M estradiol, whereas, the aldehyde oxidase activity was almost completely disappeared at the same concentration of estradiol. It implies that sex differences in lipid peroxidation is attributed to the suppression of free radical generating system by estradiol.