Ubiquitin and the Molecular Pathology of Neurodegenerative Diseases
- 1 January 2001
- book chapter
- Published by Springer Nature
- Vol. 487, 169-186
- https://doi.org/10.1007/978-1-4615-1249-3_14
Abstract
Ubiquitin is an important molecule which now appears central to several pathological cellular processesl. There is a close association between ubiquitin-protein conjugates, cytoskeletal abnormalities as well as with the endosome-lysosome system in cells. This overview concentrates on the involvement of the ubiquitin system in diseases of the nervous system, an importance which has been reinforced by recent molecular insights into neurodegenerative processes.Keywords
This publication has 133 references indexed in Scilit:
- Ubiquitin-mediated proteolysis: biological regulation via destructionBioEssays, 2000
- Expression of ?-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: Genes associated with familial Parkinson's diseaseAnnals of Neurology, 2000
- Deubiquitinating Enzymes: Their Diversity and Emerging RolesBiochemical and Biophysical Research Communications, 1999
- Are there multiple pathways in the pathogenesis of Huntington'sdisease?Philosophical Transactions Of The Royal Society B-Biological Sciences, 1999
- The Length of Polyglutamine Tract, Its Level of Expression, the Rate of Degradation, and the Transglutaminase Activity Influence the Formation of Intracellular AggregatesBiochemical and Biophysical Research Communications, 1999
- Immunohistochemical localization of ubiquitin cross‐reactive protein in human tissuesThe Journal of Pathology, 1995
- Production and characterization of monoclonal antibodies specific to multi‐ubiquitin chains of polyubiquitinated proteinsFEBS Letters, 1994
- Ubiquitin: Its potential significance in murine AA amyloidogenesisThe Journal of Pathology, 1992
- Ubiquitin conjugate immunoreactivity in the brains of scrapie infected miceThe Journal of Pathology, 1990
- Immunocytochemical and ultrastructural studies of lower motor neurons in amyotrophic lateral sclerosisAnnals of Neurology, 1990