Effect of Benoxaprofen on Release of Slow-Reacting Substances from Human Lung Tissue In Vitro
- 1 August 1982
- journal article
- research article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 63 (2) , 219-221
- https://doi.org/10.1042/cs0630219
Abstract
1. Macroscopically normal human lung tissue was obtained from operative specimens removed for lung cancer and challenged with antigen or calcium ionophore. The release of histamine and slow-reacting substances was measured by fluorimetric and bioassay techniques respectively. 2. Benoxaprofen, a drug with inhibitory effects on the lipoxygenase and cyclo-oxygenase pathways, caused a dose-related reduction of release of slow-reacting substances without affecting histamine release. 3. These results with human lung tissue in vitro suggest that benoxaprofen may be used to investigate the role of slow-reacting substances in experimental and clinical asthma.Keywords
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