Abnormal Suprarenal Discharges in Angina Pectoris and Their Control by X-ray Therapy

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Abstract
Adreno-cortical (AC) hormonal compounds, which consist of adrenalin combined with cortical sterols, were quantitatively detd. in the blood of individuals without and with angina pectoris by a colorimetric method (Endocrinology 28, 325, 1941). In angina patients the blood AC level, although generally normal at rest, showed abnormally intense. sharp elevations after physical exercise. These elevations persisted for several mins. The AC compounds which were discharged into the blood stream during physical exercise were particularly rich in adrenalin. Therapeutic roentgen irradiation of the suprarenal glands, if successful, resulted in disappearance of the abrupt AC discharges on effort, coinciding with complete or almost complete disappearance of the subjective anginal symptoms for periods of several mos. The significance of these observations is discussed from the point of view of the theory that angina pectoris upon effort is caused by the specific anoxiating effect of sudden suprarenal discharges upon the heart muscle whose O3 supply is inadequate due to sclerosis of the coronary arteries and to inability of the latter to dilate adequately.

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