Genitourinary Malignancy and Pseudohyperparathyroidism

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Abstract
Genitourinary tumors account for half of all documented cases of pseudohyperparathyroidism. The treatment of hypercalcemia is directed toward immediate correction of the electrolyte imbalance and long-term control. These goals are accomplished with volume repletion, Ca normalization and removal of the tumor. Effective therapy includes saline infusion and furosemide. Additional control is obtained with phosphates and/or indomethacin. In refractory cases actinomycin D or mithramycin is helpful. The 1st reported case of urethral cancer and 2nd reported case of testicular seminoma producing this syndrome are added to the literature.

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