Growth rate of small lung cancers detected on mass CT screening.
Top Cited Papers
- 1 December 2000
- journal article
- Published by Oxford University Press (OUP) in The British Journal of Radiology
- Vol. 73 (876) , 1252-1259
- https://doi.org/10.1259/bjr.73.876.11205667
Abstract
CT has recently been used in mass screening for lung cancer. Small cancers have been identified but the growth characteristics of these lesions are not fully understood. We identified 82 primary cancers in our 3-year mass CT screening programme, of which 61 were examined in the present study. The volume doubling time (VDT) was calculated based on the exponential model using successive annual CT images or follow-up CT images. All cases were also examined in the hospital by high resolution CT (HRCT). Lesions were divided into three types based on HRCT characteristics: type G (n = 19), ground glass opacity (GGO); type GS (n = 19), focal GGO with a solid central component; and type S (n = 23), solid nodule. 18 (95%) lesions of type G, 18 (95%) of type GS and 7 (30%) of type S were invisible on conventional chest radiographs. The mean size of the tumour was 10 mm, 11 mm and 16 mm for type G, type GS and type S, respectively. Most tumours (80%) were adenocarcinomas; 78% of these were GGO (type G and GS). Mean VDT values were 813 days, 457 days and 149 days for type G, type GS and type S, respectively; these are significantly different from each other (p < 0.05). Our results show that annual mass screening CT for 3 successive years resulted in the identification of a large number of slowly growing adenocarcinomas that were not visible on chest radiographs.Keywords
This publication has 18 references indexed in Scilit:
- Early Lung Cancer Action Project: overall design and findings from baseline screeningThe Lancet, 1999
- Mass screening for lung cancer with mobile spiral computed tomography scannerThe Lancet, 1998
- Does 2-year stability imply that pulmonary nodules are benign?American Journal of Roentgenology, 1997
- Peripheral lung cancer: screening and detection with low-dose spiral CT versus radiography.Radiology, 1996
- Tumor doubling time and prognostic assessment of patients with primary lung cancerCancer, 1994
- Management of solitary pulmonary nodulesDisease-a-Month, 1991
- Clinical and prognostic assessment of patients with resected small peripheral lung cancer lesionsCancer, 1990
- Slow-growing lung cancer in a fixed population sample radiologic assessmentsCancer, 1983
- Asymptomatic solitary pulmonary nodulesThe Journal of Thoracic and Cardiovascular Surgery, 1973
- A biomathematical approach to clinical tumor growthCancer, 1961