Suppressors of cytokine signaling and immunity
Top Cited Papers
- 24 November 2003
- journal article
- review article
- Published by Springer Nature in Nature Immunology
- Vol. 4 (12) , 1169-1176
- https://doi.org/10.1038/ni1012
Abstract
The suppressors of cytokine signaling (SOCS) and cytokine-inducible SH2 protein are key physiological regulators of the immune system. Principally, SOCS1 and SOCS3 regulate T cells as well as antigen-presenting cells, including macrophages and dendritic cells. Here we review the function of SOCS1 and SOCS3 in innate and adaptive immunity, with particular emphasis on the relationship between immune regulation and SOCS.Keywords
This publication has 79 references indexed in Scilit:
- Suppressors of cytokine signaling: Relevance to gastrointestinal function and diseaseGastroenterology, 2002
- Suppressors of cytokine signalling (SOCS) in the immune systemNature Reviews Immunology, 2002
- Cytokine Signaling in 2002Cell, 2002
- Negative Regulation of Cytokine Signaling PathwaysAnnual Review of Immunology, 2000
- SOCS/CIS Protein Inhibition of Growth Hormone-stimulated STAT5 Signaling by Multiple MechanismsJournal of Biological Chemistry, 1999
- Dual effects of suppressor of cytokine signaling (SOCS‐2) on growth hormone signal transductionFEBS Letters, 1999
- A family of cytokine-inducible inhibitors of signallingNature, 1997
- A new protein containing an SH2 domain that inhibits JAK kinasesNature, 1997
- Structure and function of a new STAT-induced STAT inhibitorNature, 1997
- Cytokine receptor signallingNature, 1995