Synthesis of 7-Substituted 5,6-Dimethyl-2,4-dioxo-1,2,4,7-tetrahydropyrrolo[2,3-d][1,3]oxazines

Abstract
The title compounds 2 are prepared by the cyclization of substituted pyrroles 3 with phosgene in refluxing tetrahydrofuran. In the case of 3a, it is shown that the cyclization can also be achieved after alkylation to give 8.

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