Genetically Determined Resistance to Infection with Group B Arbovimses. I. Distribution of the Resistance Gene among Various Mouse Populations and Characteristics of Gene Expression in Vivo

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Abstract
Resistance to group B arbovirus infection is inherited in mice as a dominant, autosomal allele. The BRVR, PRI, and C3H/RV inbred strains of mice are homozygous for this resistance. In the present study numerous other inbred strains of laboratory mice and wild Mus musculus were tested. No other inbred strain was able to resist infection with group B arboviruses; however, wild mice obtained from widely separated geographical areas were resistant to the infection. Breeding studies with one population of wild mice showed that they possessed the gene for resistance to group B arboviruses. The occurrence of this gene in wild mouse populations may indicate that it can confer selective advantage and is not merely a laboratory artifact. Levels of complement in serum were the. same in resistant and susceptible mice, cells from both resistant and susceptible mice were equally sensitive to immune cytolysis in vitro after group B arbovirus infection, and there was no evidence of a direct connection between control of body temperature and resistance to virus.

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