A Phospholipid Derivative of Cytosine Arabinoside and Its Conversion to Phosphatidylinositol by Animal Tissue
- 15 April 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 196 (4287) , 303-305
- https://doi.org/10.1126/science.191910
Abstract
We have synthesized an analog (ara-CDP-DL-dipalmitin) of cytidine diphosphate diglyceride (CDP-diglyceride) in which the antitumor drug, cytosine arabinoside, is substituted for the cytidine moiety. Enzymes in rat and human liver convert this analog to phosphatidylinositol, thereby releasing cytosine arabinoside-5 ′ -monophosphate, an obligatory intermediate in the activation of cytosine arabinoside. Unlike cytidine diphosphate diglyceride, however, ara-CDP-DL-dipalmitin is not an efficient substrate for phosphatidylglycerophosphate synthesis in liver or phosphatidylserine in Escherichia coli . The antitumor activity of ara-CDP-DL-dipalmitin in mice bearing L5178Y leukemia is described.This publication has 25 references indexed in Scilit:
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