Synthesis of 3,3-Difluoro-DL-alanine and 3,3-Difluoro-DL-alanine Precursors
- 1 January 1993
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1993 (10) , 961-963
- https://doi.org/10.1055/s-1993-25979
Abstract
The key intermediate to 3,3-difluoroalanine, 2,2-difluoro-1-ethylthioethylamine hydrobromide (2), was prepared by the Steglich and Weygand procedure. Its conversion to N-benzyloxycarbonyl-2,2-difluoro-1-ethenylethylamine (5) followed by oxidation and subsequent deprotection of the amine afforded the 3,3-difluoroalanine.Keywords
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