Conformational effects on the activity of drugs. 7. Synthesis and pharmacological properties of 2-(p-nitrophenyl)-substituted morpholines
- 31 May 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 22 (6) , 738-741
- https://doi.org/10.1021/jm00192a023
Abstract
A series of 1-(p-nitrophenyl)-2-aminoethanol derivatives and their morpholine analogs were synthesized and pharmacologically studied to confirm observations made with the N-isopropyl-substituted compounds. The weak .alpha.-adrenergic-stimulating activity and the potentiating effect on the responses to norepinephrine found in the open-chain compounds persist in their corresponding semirigid cyclic analogs. The results are discussed in the light of common knowledge of the structure-activity relationships of .alpha.-adrenergic drugs.This publication has 0 references indexed in Scilit: