The rare Lutheran blood group phenotype Lu(a–b–): a genetic study
- 1 July 1984
- journal article
- Published by Wiley in Annals of Human Genetics
- Vol. 48 (3) , 229-237
- https://doi.org/10.1111/j.1469-1809.1984.tb01019.x
Abstract
The rare blood group phenotype lacking Lutheran antigens, Lu(a–b–), is known to have two genetic backgrounds. Tests on 250000 blood donors show the frequency of Lu(a–b–) to be approximately 1 in 3000. The families of 41 propositi show the dominant inhibitor of Lutheran antigens, In(Lu), to be the usual cause of the phenotype in South East England; there was no proven case of the recessive background, LuLu. Lod scores for In(Lu) and other blood group loci are presented; the only hint of linkage is between In(Lu) and Rh. The suppressing effect of In(Lu) on the expression of antigens of unrelated blood group systems, P1, Aua and i, is confirmed.Keywords
This publication has 12 references indexed in Scilit:
- Serological Characteristics of the Third Anti-AuaVox Sanguinis, 1982
- TWO MONOCLONAL ANTIBODIES DETECTING HIGH FREQUENCY ANTIGENS ABSENT FROM RED CELLS OF THE DOMINANT TYPE OF Lu (a‐b‐) Lu:‐3International Journal of Immunogenetics, 1982
- A family demonstrating the independence between lutheran and Auberger lociRevue Française de Transfusion et Immuno-hématologie, 1981
- Two Kindred with the Rare Dominant Inhibitor of the Lutheran and P1 Red Cell AntigensHuman Heredity, 1975
- The Lu(a‐b‐) Syndrome and an Apparent Upset of P1 InheritanceVox Sanguinis, 1974
- Antigens Aua, i and P1 of Cells of the Dominant Type of Lu(a–b–)Vox Sanguinis, 1974
- The Recessive Lu(a-b-) PhenotypeVox Sanguinis, 1974
- The Genetics of a Dominant Inhibitor of the Lutheran AntigensVox Sanguinis, 1973
- The Lu(a‐b‐) Phenotype: An Additional ExampleVox Sanguinis, 1967
- A “New” Antibody Anti-LuaLub and Two Further Examples of the Genotype Lu(a–b–)Nature, 1963