Further Observations on the Prevention of Pasture Bloat by the Use of Antibiotics in Rotation or in Combination

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Abstract
A rotation of antibiotics was fed sequentially in grain, each antibiotic being fed for a 1-week period. The rotation, consisting of penicillin (P), erythromycin (E), tylosin (T), chloramphenicol (C), oxytetracycline (O) and streptomycin (S), prevented serious bloat during the initial 6-week period. Two subsequent repetitions of the cycle indicated that penicillin regained effectiveness in the least time (about 6 weeks). The most effective treatment over a prolonged period was a combination of P, E, T, C and O fed in grain, which provided protection over the entire period (May to Sept.) in which it was fed. A water-administered combination of P, E and T prevented bloat for about 7 weeks. A weekly rotation of P, E and T seemed to be effective when given in the drinking water, but the water-administration of C which followed was ineffective, probably due to its poor solubility and low water stability. The average weight gains of the groups receiving antibiotics in rotation and in combination were much greater than those of control animals. Copyright © . .

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