Conserved non-genic sequences — an unexpected feature of mammalian genomes
- 1 February 2005
- journal article
- review article
- Published by Springer Nature in Nature Reviews Genetics
- Vol. 6 (2) , 151-157
- https://doi.org/10.1038/nrg1527
Abstract
Mammalian genomes contain highly conserved sequences that are not functionally transcribed. These sequences are single copy and comprise approximately 1–2% of the human genome. Evolutionary analysis strongly supports their functional conservation, although their potentially diverse, functional attributes remain unknown. It is likely that genomic variation in conserved non-genic sequences is associated with phenotypic variability and human disorders. So how might their function and contribution to human disorders be examined?Keywords
This publication has 56 references indexed in Scilit:
- Initial sequencing and comparative analysis of the mouse genomeNature, 2002
- Numerous potentially functional but non-genic conserved sequences on human chromosome 21Nature, 2002
- A Comparison of Whole-Genome Shotgun-Derived Mouse Chromosome 16 and the Human GenomeScience, 2002
- Generation and Comparative Analysis of ∼3.3 Mb of Mouse Genomic Sequence Orthologous to the Region of Human Chromosome 7q11.23 Implicated in Williams SyndromeGenome Research, 2002
- Evolutionarily Conserved Sequences on Human Chromosome 21Genome Research, 2001
- Conserved noncoding sequences are reliable guides to regulatory elementsTrends in Genetics, 2000
- Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence ComparisonsScience, 2000
- Proneural gene self-stimulation in neural precursors: an essential mechanism for sense organ development that is regulated byNotch signalingGenes & Development, 1998
- Long Human–Mouse Sequence Alignments Reveal Novel Regulatory Elements: A Reason to Sequence the Mouse GenomeGenome Research, 1997
- Strong conservation of non-coding sequences during vertebrates evolution: potential involvement in post-transcriptional regulation of gene expressionNucleic Acids Research, 1993