RESPONSE OF 3 CLASSES OF HUMAN ERYTHROID PROGENITORS TO THE ABSENCE OF ERYTHROPOIETIN INVITRO AS A MEASURE OF PROGENITOR MATURITY

  • 1 January 1981
    • journal article
    • research article
    • Vol. 9  (10) , 1035-1041
Abstract
The effect of erythropoietin (Ep) deprivation (epoprival state) on plasma clot cultures of human bone marrow and peripheral blood erythroid progenitors was examined. In normal individuals, there was a marked reduction of CFUE [erythroid colony-forming units] derived colony expression if Ep was withheld from the culture for even 1 day. Peripheral blood BFUE [erythropoietic burst-forming cells] retained substantial function during the epoprival state for up to 2-5 days while bone marrow-derived BFUE had intermediate sensitivity. The capacity of erythroid progenitors to withstand incubation in semi-solid media in the absence of EP is a characteristic of immature, rather than mature, erythroid progenitors.

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