Production of Edema in Rats by Local Anesthetics

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Abstract
The edema producing properties of lidocaine, mepevicaine and pro-caine were determined by subcutaneous injection of each compound into the flank of rats and determining the water content of a 10 x 10 mm biopsy taken from the area 24 hours later. The results indicate that lidocaine, mepevicaine and procaine all produce edema, with procaine inducing less fluid accumulation in the rat skin than the other 2 drugs. This study also showed that it was the local anesthetic, and not the vasoconstrictor or preservative of the local anesthetic solutions, which produced the edema.