THE EFFECT OF A HISTAMINASE-INHIBITOR (AMINOGUANIDINE) ON PREGNANCY IN THE RAT

Publisher Website
Google Scholar
Abstract
SUMMARY: 1. Aminoguanidine sulphate can inhibit in vitro the histaminase of rat placental extracts; given subcutaneously, it can also inhibit in vivo the placental and uterine histaminase of pregnant rats. 2. Aminoguanidine sulphate given subcutaneously to pregnant rats in doses producing more than about 50% inhibition of the maternal placental histaminase leads to a general disturbance of the course of pregnancy. The foetuses are more sensitive than the mother. 3. The results provide evidence that the great increase of placental and uterine histaminase during rat pregnancy plays an important part in maintaining pregnancy and bringing it to a successful conclusion.

This publication has 3 references indexed in Scilit: