Triazolam and ethanol interaction: Kinetic and dynamic consequences

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Abstract
The kinetic and dynamic consequences of the coadministration of triazolam and ethanol were investigated in 6 normal subjects. Each received 3 treatments: triazolam, 0.25 mg by mouth, preceded by 1 h and followed for 7.5 h by oral ethanol dosed to maintain breath concentrations of 800-950 mg/l; placebo and ethanol; and triazolam and orange juice. After ethanol, triazolam total AUC0.infin. [area under the concentration curve] increased (.hivin.X [mean] .+-. SD = 21% .+-. 18%). Subjects showed greater psychomotor impairment on measures of free recall, postural stability and hand-eye coordination after the combination than after either drug alone. These dynamic interactions are greater than the kinetic changes.