Bath administration of the quinoline antibiotic flumequine to brown trout Salmo trutta and Atlantic salmon S. salar

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Abstract
Administration of flumequine to brown trout Salmo trutta and Atlantic salmon Salmo salar, using bath treatments, resulted in significant serum levels of the antibiotic. Bath concentrations of 50, 100 and 500 ppm were tested for up to 5 h. Temperature, pH, and calcium hardness of the bath water were all found to influence serum levels achieved, as did the level of the drug in the bath. Following bath treatment, serum levels of flumequine greater than the minimum inhibitory concentrations for most susceptible fish pathogens were maintained for up to 14 d. Flumequine serum levels eliciting a toxic response in treated fish were determined. The efficacy of flumequine bath treatments in the control of furunculosis, caused by Aeromonas salmonicida, has been established and its application as both a prophylactic and a chemotherapeutic method for the control of bacterial infections is proposed.

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