CYTOMEGALOVIRUS ENDOLABYRINTHITIS

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 101  (3) , 118-121
Abstract
A premature male infant, who died 22 days after birth with hyaline membrane disease, had cytomegalic inclusion disease at autopsy. Histopathologic examination of the temporal bones showed cytomegalovirus (CMV) infection of the entire endolabyrinth without involvement of the neural and sensory structures. Late gestational or perinatal fetal CMV infection apparently results in an endolymphatic labyrinthitis. Blood-borne virus may pass from the stria vascularis into the endolymphatic spaces and infect the nonneurosensory epithelium. This pattern of infection differs from the perilabyrinthitis of human varicella-zoster and experimentally produced mouse CMV.

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