Epithelial Cell Differentiation--a Mather of Choice

7 December 2001

journal article
editorial
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 294 (5549) , 2115-2116
https://doi.org/10.1126/science.1067751

Abstract

The epithelium of the gut is composed of four different cell types that differentiate from a common progenitor stem cell pool in the crypts. But what are the signals that influence progenitor cells to adopt one of four possible cell fates? In a Perspective, van den Brink et al. discuss new findings ( Yang et al.) that identify the transcription factor, Math1, as an important mediator of cell fate choice by gut epithelial progenitor cells.

Keywords

This publication has 13 references indexed in Scilit:

Requirement of Math1 for Secretory Cell Lineage Commitment in the Mouse Intestine
Science, 2001
Sonic hedgehog regulates gastric gland morphogenesis in man and mouse
Gastroenterology, 2001
Proprioceptor Pathway Development Is Dependent on MATH1
Neuron, 2001
Stem cells and the regulation of proliferation, differentiation and patterning in the intestinal epithelium: emerging insights from gene expression patterns, transgenic and gene ablation studies
Mechanisms of Development, 2001
Downregulation of Hedgehog Signaling Is Required for Organogenesis of the Small Intestine in Xenopus
Developmental Biology, 2001
The bHLH Gene Hes1 Regulates Differentiation of Multiple Cell Types
Molecules and Cells, 2000
Notch signalling and the control of cell fate choices in vertebrates
Seminars in Cell & Developmental Biology, 1998
Proneural function of neurogenic genes in the developing Drosophila eye
Current Biology, 1997
HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo
Developmental Biology, 1995
Chimeric-transgenic mice represent a powerful tool for studying how the proliferation and differentiation programs of intestinal epithelial cell lineages are regulated.
Proceedings of the National Academy of Sciences, 1993