RESPONSES TO ISOPROTERENOL IN A GENERAL POPULATION-SAMPLE

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Abstract
The response of forced expiratory flow to inhalation of isoproterenol was evaluated in a general population sample of 1063 subjects. Percentage changes in the forced expiratory volume in 1 s and in the maximal flow measured at 50% of the initial expired forced vital capacity appeared to be the best indicators of responsiveness to bronchodilator. Subjects with a history of asthma more often showed responsiveness than did the remainder of the population, even when their initial function was within normal limits. Over-all, a high proportion of subjects with abnormalities in baseline forced expiratory volume in 1 s or maximal flow after exhalation of 50% of the forced vital capacity showed sufficient improvement after bronchodilator to cause their values after isoproterenol to fall within the normal range. Responsiveness to bronchodilator aerosol may be a useful guide to the presence of bronchial reactivity in epidemiologic studies of obstructive airway diseases.

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