Suppression of adjuvant‐induced arthritis in da rats by incomplete freund's adjuvant
- 1 January 1993
- journal article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 36 (1) , 126-131
- https://doi.org/10.1002/art.1780360120
Abstract
Objective. To define the effects of incomplete Freund's adjuvant (ICFA) on subsequent arthritis induced by complete Freund's adjuvant (CFA) and type II collagen (CII) in DA and Lewis rats. Methods. ICFA was injected into DA and Lewis rats before CFA or CII injection. Results. DA rats previously injected with ICFA had significantly less severe arthritis induced by CFA compared with those not receiving ICFA pretreatment (P Conclusion. The injection of ICFA alone specifically suppresses subsequent CFA‐induced arthritis in DA rats, but not in Lewis rats.Keywords
This publication has 11 references indexed in Scilit:
- The effects of flurbiprofen on the passive transfer of adjuvant-induced arthritisInflammation Research, 1992
- Heat‐Shock Proteins as Immunogenic Bacterial Antigens with the Potential to Induce and Regulate Autoimmune ArthritisImmunological Reviews, 1991
- Induction of arthritis in rats by aqueous suspensions of mycobacteria without the use of oilArthritis & Rheumatism, 1991
- Prevention of adjuvant arthritis in rats by a nonapeptide from the 65-kD mycobacterial heat-shock proteinClinical and Experimental Immunology, 1990
- Homologous type ii collagen—induced arthritis in ratsArthritis & Rheumatism, 1990
- Treatment of adjuvant arthritis in rats: Vaccination potential of a synthetic nonapeptide from the 65 kDa heat shock protein of mycobacteriaJournal of Autoimmunity, 1990
- A mycobacterial 65-kD heat shock protein induces antigen-specific suppression of adjuvant arthritis, but is not itself arthritogenic.The Journal of Experimental Medicine, 1990
- Immunogenetic control of experimental type ii collagen‐induced arthritisArthritis & Rheumatism, 1981
- Differences in the Severity of Adjuvant Arthritis in Four Strains of RatsExperimental Biology and Medicine, 1969
- Studies on adjuvant‐induced polyarthritis in rats. I. Adjuvant composition, route of injection, and removal of depot siteArthritis & Rheumatism, 1962