Effects of dietary saturated andTrans fatty acids on tissue lipid composition and serum LCAT activity in the rat
- 1 April 1976
- Vol. 11 (4) , 272-280
- https://doi.org/10.1007/bf02544053
Abstract
Groups of rats were fed from weaning with diets containing 5% by wt of hydrogenated coconut oil (HCO), safflower oil, or a concentrate of ethyl elaidate and linolelaidate (TRANS) as the sole source of dietary fat. Fatty acid composition of the lipid classes from serum, liver, heart, and kidney was determined, and the serum lecithin: cholesterol acyl transferase (LCAT) activities were assayed for each animal. Serum LCAT activity was increased by both the HCO and TRANS diets in the early stages of the development of an essential fatty acid (EFA) deficiency but was suppressed in the animals of the TRANS group as they became older. The HCO and TRANS groups exhibited changes in tissue lipid fatty acid composition, as well as reduced growth, characteristic of an EFA deficiency. Conversion of oleic acid to eicosatrienoic acid was impaired in the animals fed the TRANS diet, greatly increasing the octadecenoic acid content of the tissue lipids at the expense of eicosatrienoic acid. The TRANS diet also suppressed incorporation of eicosatrienoic acid into cholesteryl esters of tissue and serum, indicating that, when fed as the sole source of unsaturated fat,trans fatty acids influenced the metabolism of unsaturated fatty acids and cholesterol.This publication has 42 references indexed in Scilit:
- Dependence of sterol ester hydrolase activity on the position of ethylenic bond in cholesteryl cis-octadecenoatesBiochemistry, 1970
- Effect of geometry and position of ethylenic bond upon acyl coenzyme A-cholesterol-O-acyltransferaseBiochemistry, 1970
- Hydrolysis of synthetic cholesterol esters containing trans fatty acidsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1968
- The catabolism of the geometric isomers of uniformly 14C-labeled δ9-octadecenoic acid and uniformly 14C-labeled δ9,12-octadecadienoic acid by the fasting ratBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1967
- Physical studies of phospholipids II. Monolayer studies of some synthetic 2,3-diacyl-dl-phosphatidylethanolamines and phosphatidylcholines containing trans double bondsBiochimica et Biophysica Acta (BBA) - Biophysics including Photosynthesis, 1966
- A comparison of acyltransferase activities in vitro with the distribution of fatty acids in lecithins and triglycerides in vivoLipids, 1966
- Essential fatty acid deficiency and cholesterol esterification activity of plasma and liver in vitro and in vivoArchives of Biochemistry and Biophysics, 1965
- Fatty acid specificities and rates of cholesterol esterification in vivo and in vitroArchives of Biochemistry and Biophysics, 1964
- Conditions D'incorporation des acides gras élaïdisés aux triglycérides de réserve du rat blancBiochimica et Biophysica Acta, 1963