Metabolism of 14C-Rhein and 14C-Rhein Anthrone in Rats
- 1 January 1988
- journal article
- Published by S. Karger AG in Pharmacology
- Vol. 36 (1) , 152-157
- https://doi.org/10.1159/000138435
Abstract
The two radioactive compounds were administered intracaecally to rats, and the recovery rates amounted to 89.9% for 14C-rhein and to 97.4% for 14C-rhein anthrone after 5 days. All organs and tissues showed for both compounds a significant clearance of radioactivity with exception of the kidneys where high levels persisted even after 5 days. Different metabolites could be detected in urine as well as in faeces where also nonanthraquinone fractions could be found.Keywords
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