The insulin-regulatable glucose transporter GLUT-4

Publisher Website
Google Scholar
Abstract
Insulin activates glucose transport in muscle and adipose (issue by stimulating the movement of a facilitative glucose transporter, GLUT-4, from an intracellular compartment to the cell surface. The molecular regulation of GLUT-4 is very similar to the regulated movement of secretory vesicles in neural and endocrine cells, suggesting that these types of pathways may exist in a wide variety of cells in order to serve many different needs. Candidate signal transduction pathways have been carefully scrutinized. Whereas the Ras-mitogen-activated protein kinase pathway is not likely to be involved, a role for phosphatidylinositol-3′-kinase in insulin-regulated glucose transport has been ascertained.

This publication has 0 references indexed in Scilit: