Reabsorption of Inorganic Sulfate by the Renal Tubules of the Rat

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Abstract
Reabsorption of inorganic sulfate by the renal tubules was measured in the rat by means of a constant infusion technique. Plasma sulfate concentration was varied between 1.1 and 4.6 μmole/ml. When glomerular filtration rate was measured by inulin clearance there seemed to be reabsorption at low sulfate levels but secretion at higher levels. When polyethylene glycol of molecular weight 1,000 or 400 was used instead of inulin, the calculated values for glomerular filtration rate were almost twice as high, and reabsorption of filtered sulfate exhibited a Tm (transfer maximum) of 1.02 μmole/ml glomerular filtrate. The Tm is of the same order of magnitude as in the dog (1.65 μmole/ml glomerular filtrate) and man (0.97 μmole/ml glomerular filtrate). Carinamide had no effect, indicating that tubular secretion of sulfate is absent or insignificant. Neither did phlorizin have any effect, contrary to expectations from earlier experiments on the intact dog and on kidney cortex slices of the rat.

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