Characterization of Iopromide-Carrying Liposomes

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Abstract
Iopromide-carrying liposomes were prepared by the ethanol evaporation method and pharmacokinetic parameters and CT imaging efficiency were determined in rats and rabbits. The mean diameter of the liposomes was 0.5±0.1 urn and the encapsulation efficiency was between 30 and 40%. The liposomes were stable in human, bovine, dog, pig, rat and rabbit plasma for more than 6 h. The pharmacokinetics in rats and rabbits were dose-dependent. Increasing the dose resulted in lower total clearance, and longer terminal half-life. Elimination of iodine was complete and the main route of excretion was via the kidneys. A clinically relevant CT enhancement of the liver was reached after 200 mg iodine/kg in rat and 150 mg iodine/kg in rabbit.