Regulatory Mechanisms for Protein Synthesis in Normal Blood Cells

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Abstract
The experi-mental results obtained by autoradiographic techniques, on the RNA [ribonucleic acid] and protein metabolism of normal differentiating blood cells and of peripheral blood mononuclear cells, are reviewed and discussed. The data suggests 2 different mechanisms for the regulation of protein synthesis: The 1st, characteristic of differentiating cellular systems, follows the general principles of the operon model, involving the progressive repression of messenger formation. The 2nd, pertaining to lymphoid cells and possibly mono-cytes, conforms to the scheme outlined by Stent and consists in a regulation of messenger function brought about by variations in the intracellular availability of transfer RNAs.

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