3-HYDROXYDECANEDIOIC ACID AND RELATED HOMOLOGS - URINARY METABOLITES IN KETOACIDOSIS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 26  (2) , 261-265
Abstract
Urine from patients with ketoacidosis [due to diabetes mellitus or undefined metabolic disorders] contained a number of aliphatic 3-hydroxy dicarboxylic acids. The acids were purified by silicic acid chromatography and their structures were determined by gas chromatography-mass spectrometry of different derivatives. The major compound was 3-hydroxydecanedioic acid. Minor compounds were 3-hydroxyoctanedioic acid, 3-hydroxyoctenedioic acid, 3-hydroxydecenedioic acid, 3-hydroxydodecanedioic acid, 3-hydroxydodecenedioic acid, 3-hydroxytetradecenedioic acid and 3-hydroxytetradecadienedioic acid. The excretion of 3-hydroxydecanedioic acid correlated positively with excretion of hexanedioic acid, another metabolite constantly found in ketoacidosis. The 3-hydroxy dicarboxylic acids are apparently formed from fatty acids by a combination of .omega.-oxidation and incomplete .beta.-oxidation.

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