Effect of New Adrenal Steroids on Electrolyte and Water Excretion

Publisher Website
Google Scholar
Abstract
Effects of prednisone, prednisolone, hydrocortisone and desoxycorticosterone on excretion of water, Na, and K, were compared in water-loaded adrenalectomized rats. All steroids stimulated water diuresis and K excretion. Hydrocortisone, prednisone and prednisolone were equi-potent; desoxycorticosterone was weaker. Hydrocortisone, prednisone and prednisolone stimulated Na excretion at all doses having any effect and were again approximately equi-potent. Desoxycorticosterone had the opposite effect and caused Na retention. The relative inability of the delta1-steroids to cause Na retention under conditions of clinical use is, therefore, not associated with any comparable inability to cause natriuresis under appropriate circumstances.