Synthesis of [1-(D-2-hydroxy-3-mercaptopropanoic acid)]oxytocin, a diastereoisomer of the hydroxy-isostere of oxytocin
- 1 January 1974
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- Vol. 2, 202-205
- https://doi.org/10.1039/p19740000202
Abstract
[1-(D-2-Hydroxy-3-mercaptopropanoic acid)]oxytocin was synthesized by azide coupling of O-benzyl-N-(D-3-benzylthio-2-hydroxypropanoyl)-L-tyrosine hydrazide with a heptapeptide. The hormone analogue had an uterotonic activity of 27·3 i.u. mg–1 and did not bind to neurophysin.Keywords
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