Intrahippocampal Wortmannin Infusion Enhances Long-Term Spatial and Contextual Memories
Open Access
- 1 July 2002
- journal article
- Published by Cold Spring Harbor Laboratory in Learning & Memory
- Vol. 9 (4) , 167-177
- https://doi.org/10.1101/lm.50002
Abstract
The transition from short- to long-term memory involves several biochemical cascades, some of which act in an antagonistic manner. Post-training intrahippocampal administration of wortmannin, a pharmacological inhibitor of phosphatidylinositol 3-kinase, had no effect on memory tested 3 h later, but improved long-term memory tested 48 h following the completion of training. This effect was seen in two hippocampus-dependent tasks: the Morris water maze, using both massed and distributed training paradigms, and contextual fear conditioning. The improvement of long-term memory appears to be the result of enhanced consolidation, as wortmannin had no effect on memory recall. These results are consistent with the hypothesis that memory consolidation involves competing processes, and that blockade of an inhibitory constraint facilitates the consolidation process.Keywords
This publication has 54 references indexed in Scilit:
- Interaction between Amount and Pattern of Training in the Induction of Intermediate- and Long-Term Memory for Sensitization in AplysiaLearning & Memory, 2002
- Long-term potentiation in dentate gyrus of the rat is inhibited by the phosphoinositide 3–kinase inhibitor, wortmanninNeuropharmacology, 2000
- Expression, Enzyme Activity, and Subcellular Localization of Mammalian Target of Rapamycin in Insulin-Responsive CellsBiochemical and Biophysical Research Communications, 1997
- Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural changeCell, 1995
- Induction of a dominant negative CREB transgene specifically blocks long-term memory in DrosophilaCell, 1994
- Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.Behavioral Neuroscience, 1992
- Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.Behavioral Neuroscience, 1992
- Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.Psychological Review, 1992
- Selective impairment of long-term but not short-term conditional fear by the N-methyl-D-aspartate antagonist APV.Behavioral Neuroscience, 1992
- cAMP-dependent protein kinase and the disruption of learning in transgenic fliesNeuron, 1991